Effect of warfarin on experimental calcium oxalate stone formation in rats
- VernacularTitle:苄丙酮香豆素对实验性大鼠肾草酸钙结石形成的影响
- Author:
Haoyong LI
;
Kai LI
;
Jihong LIU
- Publication Type:Journal Article
- Keywords:
Kidney calculi;
Calcium oxalate;
Warfarin;
Animal,laboratory
- From:
Chinese Journal of Urology
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of warfarin on the formation of renal calcium oxalate stones induced by 1% ethylence glycol (EG) and 3% ammonium chloride (NH 4Cl) in rats. Methods 30 adult male Wistar rats were randomized to three groups,the control group (A) being non-treated,the stone group (B) rats taken EG and NH 4Cl,and the warfarin group (C) taken warfarin in addition to EG and NH 4Cl.All rats were bred 4 weeks.The renal tissue calcium,the renal calcium oxalate crystallization,and the urinary calcium excretion and serum biochemical data were detected. Results No significant difference has been noted in 3 groups,although there is a tend that number of ranal calcium oxalate crystals in group C was more than that in group B. Conclusions The results denoted that warfarin had no significant effect on the calcium oxalate crystallization in rats.
