Entubulization nerve reconstruction in the experimental rat resulting in return of erectile function
- VernacularTitle:神经套管术重建勃起功能的动物实验研究
- Author:
Liquan HU
;
Xinjun SU
;
Shiwen LI
- Publication Type:Journal Article
- Keywords:
Impotence;
Nerve fiber;
Animals,laboratory
- From:
Chinese Journal of Urology
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the feasibility of repairing surgically ablated cavernous nerves with silastic nerve tube conduit filled with nerve growth enhancing media. Methods 54 male adult Sprague-Dawley rats were randomized into 3 groups,the sham operated controls,the bilateral cavernous nerve ablation and entubulization nerve reconstruction with insulin like growth factor(IGF).1,3 and 6 months after surgery,rats models were evaluated with apomorphine test,followed by nicotinamide adenine dinucleotide phosphate (NADPH) diaphorase staining to identify NOS in penile nerve fibers of the proxiamal portion of penile shaft and penile crus. Results There was no statistically significant difference between the ablated and the entubulization nerve reconstruction groups at 1 month,however,at 3 and 6 months,Apomorphine test studies resulted in tumescence from 42% and 50% of the entubulization nerve reconstruction groups versus 0% and 0% of the ablated group,respectively (P
