Nonmyeloablative allogeneic peripheral blood stem cell transplantation for chronic leukemia:a report of seven cases
- VernacularTitle:非清髓性异基因外周血造血干细胞移植治疗慢性白血病七例报告
- Author:
Changlin YU
;
Huisheng AI
;
Chunhua ZHAO
- Publication Type:Journal Article
- Keywords:
Hemotopoietic stem cell transplantation;
Transplantation,homologous;
Transplantation conditioning
- From:
Chinese Journal of Organ Transplantation
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To summarize the experimence of nonmyeloablative allogeneic peripheral blood cell transplantation in the treatment of chronic leukemia. Methods Seven patients, including 6 cases of chronic myeloid leukemia (in chronic phase), one of chronic lymphoid leukemia (in third stage), with HLA-identical siblings donor received allogeneic peripheral blood stem cell transplantation after a nonmyeloablative conditioning. Results All of them were engrafted with donor cells (4 with full of donor cells grafted, 3 with mixed chimerism) and recovered hematopoiesis (WBC recovered to more than 0.5 ?10 9/L during postoperative 9 day to 21 day and platelet recovered to more than 30?10 9/L during postoperative 11 day to 28 day). One of them developed a GVHD of degree IV. One of them developed aGVHD of degree I. Conclusion This procedure is much safe, effective and of less complications than the myeloablative condioning regimens and may represent another new approach in the management of patients with chronic leukemia.
