A comparison of long-term effect and safety between tacrolimus and cyclosporine in cadaveric renal transplantation
- VernacularTitle:他克莫司与环孢素A在尸肾移植中应用的长期疗效和安全性比较
- Author:
Lizhong CHEN
;
Changxi WANG
;
Jiguang FEI
- Publication Type:Journal Article
- Keywords:
Tacrolimus;
Cyclosporine;
Kidney transplantation;
Treatment outcome
- From:
Chinese Journal of Organ Transplantation
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the long-term effect and safety between tacrolimus (FK506) and cyclosporine (CsA) in patients receiving cadaveric renal transplantation. Method A total of 210 patients were randomized to FK506 and CsA after cadaveric renal transplantation, and were followed up for 12-32 months for the variation of trough concentration in whole blood, the incidence of acute rejection and chronic rejection, one-year survival rate of patient/graft, variation of creatinine level, impairment of liver function and glucose metabolism and lipid metabolism, incidence of infection, and side effects. Results The variation of trough concentration of FK506 was similar to CsA. The incidence of acute rejection was significantly lower in FK506 group than in CsA group ( 16.3 % vs 33.0 % , P 0.05 ). The incidence of impaired liver function and impaired lipid metabolism and gingivitis and creatinine level three months after transplantation were significantly lower in FK506 group than in CsA group ( P
