Association of Glu298Asp polymorphism of the endothelial nitric oxide synthase gene with myocardial infarction in the elderly patients
- VernacularTitle:血管内皮型一氧化氮合酶基因Glu298Asp多态性与老年心肌梗死的关系
- Author:
Yiyang ZHAN
;
Qun DI
;
Yunlin CHENG
;
Xiaojian DING
- Publication Type:Journal Article
- Keywords:
Nitric-oxide synthase;
Myocardial infarction
- From:
Chinese Journal of Geriatrics
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association of Glu298Asp polymorphism of the endothelial nitric oxide synthase gene (eNOS) with myocardial infarction in Chinese aged people based on a case-control study. Methods Thirty-seven patients with myocardial infarction and 172 sex- and age-matched healthy control subjects were enrolled. Their height, weight and blood pressure were measured and the fasting plasma lipid concentrations were examined. Glu298Asp polymorphisms of the eNOS gene were examined using PCR and RFLP methods. Results Genotype Glu/Asp in the patient group was higher than that in the control group (32.4% vs 18.0%). The genotype composition of Glu298Asp polymorphism showed significant difference between the patient group and the control group ( =3.87, P 0.05). Among the normotensive subgroup, the allelic frequencies of 298Asp in the patient subgroup was higher than that in the control subgroup (17.5% vs 5.4%). The allelic frequencies of 298Asp had significant difference between the patient subgroup and the control subgroup ( =6.82, P
