Differential diagnostic usefulness of CK19, S-100 protein and EMA in papillary carcinoma and papillary hyperplasia
- VernacularTitle:CK19,S-100和EMA在鉴别甲状腺乳头状癌与乳头状增生中的作用
- Author:
Min WANG
;
Honghui HU
- Publication Type:Journal Article
- Keywords:
thyroid neoplasms, cytokeratin 19, S-100 protein, epithelial membrane antigen, papillary hyperplasia, immunohistochemistry
- From:China Oncology
1998;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose: To evaluate the diagnostic utility of detection of Cytokeratin 19 (CK19), b-100 protein and epithelial membrane antigen ( EMA) in thyroid papillary carcinoma, follicular carcinoma and papillary hyperplasia. Methods: 65 thyroid lesions were stained immunohistochemically for CK19, S-100 protein and EMA. Results: CK19, S-100 and EMA are negative in all papillary hyperplasia. CK19 expression was strong and diffuse in 100% of papillary carcinoma including the follicular variant of papillary carcinoma, and was positive in 22% of follicular carcinoma. S-100 and EMA were respectively present in 61% and 100% of classic papillary carcinoma, in 38% and 54% of follicular variant of papillary carcinoma and in 44% and 11 % of follicular carcinoma. Conclusions: Our observations suggest that the expression of CK19, in combination with S-100 and EMA expression, is helpful in the diagnosis of thyroid lesions. CK19 is a valuable marker in the distinction of papillary carcinomas from papillary hyperplasia.
