Chemokine and breast cancer metastasis
- VernacularTitle:趋化性细胞因子与乳腺癌的转移
- Author:
Xiaoying YAO
;
Hui SONG
;
Dajin LI
- Publication Type:Journal Article
- Keywords:
chemokine;
chemokine receptor;
breast cancer;
metastasis
- From:
China Oncology
1998;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Breast cancer metastasis is the main cause of tumor death and poor long-term effect in clinical treatment. In the process of metastasis, chemokine may play the main role. In the breast cancer cell, some chemokine and receptor were expressed excessively. It has been shown that through the interaction between chemokine and correspondence receptor, phagocyte and lymphocyte infiltration stimulated, tumor cell invasion into normal tissue with angiogenesis, thus the metastasis was formed. This article reviews the mechanisms of chemokine receptor CXCR4 and chemokine RANTES ,IL-8 MCP-1 in breast cancer metastasis.
