Relationship between serum acute-phase proteins and diabetic nephropathy in type 2 diabetic patients
- VernacularTitle:2型糖尿病患者急性时相蛋白与糖尿病肾病的关系
- Author:
Bing HE
;
Ping HAN
;
Xianke LU
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus, non-insulin-dependent;
Diabetic nephropathies;
Acute-phase proteins
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the levels of serum acute phase protein in different stages of diabetic nephropathy and their implication. Methods This study included 30 healthy subjects and 100 patients with type 2 diabetes mellitus, diabetic patients were further divided into three subgroups according to their urinary albumin excretion rate (UAER): 39 patients with normal UAER, 30 patients with microalbuminuria and 31 patients with clinical proteinuria. C-reactive protein, ? 1-acid glycoprotein (? 1-AAG), ceruloplasmin (CER) were measured with rate nephelometry method, sialic acid was measured with MTT method. Results (1) Acute phase protein concentrations were significantly higher in patients of type 2 diabetes mellitus than those in normal controls. (2) Acute phase protein concentrations were increased with increment of UAER. (3) Some acute phase proteins (? 1-AAG, CER and SA) were correlated with serum cholesterol and triglyceride independently. Conclusion There is acute phase reaction in type 2 diabetes mellitus and the degree of acute phase reaction is correlated with the degree of diabetic nephropathy.
