Islet ?-cell function in the patients with latent autoimmune diabetes of adults: a prospective study
- VernacularTitle:LADA患者胰岛?细胞功能的前瞻性研究
- Author:
Lin YANG
;
Zhiguang ZHOU
;
Gan HUANG
;
Xiang YAN
;
Lingli OUYANG
;
Hanwen WU
- Publication Type:Journal Article
- Keywords:
Latent autoimmune diabetes of adults;
Islet ?-cell function;
Antibody, glutamate decarboxylase;
Autoantibodies
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the characteristics of ? cell function change and to explore the predictive value of glutamic acid decarboxylase (GAD)-Ab and other factors for ? cell function in the patients with latent autoimmune diabetes of adults (LADA). Methods Sixteen LADA patients (positive GAD-Ab) and 24 type 2 diabetic patients (negative GAD-Ab) were followed-up at 0, 6th, 12th, 30th, 36th, 42th and 48th months respectively. Their fasting and postprandial 2h C-peptide and glycemic control were measured. GAD-Ab was determined by radioimmunoprecipitation assay and C-peptide by RIA. Results Decreased fasting C peptide (FCP) levels (Month 30, 36, 42, 48 compared with Month 0, P
