On the endothelium-dependent vasodilation function in insulin-resistant rats
- VernacularTitle:胰岛素抵抗大鼠内皮依赖性血管舒张功能研究
- Author:
Jian DU
;
Xiaojuan ZHAO
;
Guoliang LIU
- Publication Type:Journal Article
- Keywords:
Insulin resistance;
Euglycemic hyperinsulinemic clamp technique;
Endothelium-dependent vasodilatation;
Nitric oxide
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the change of endothelium-dependent vasodilatation function and to explore its mechanism in insulin-resistant (IR) rats induced by high fat feed. Methods (1) IR rat model was established by high fat feed for 4 weeks and IR was evaluated by glucose infusion rate (GIR) of euglycemic hyperinsulinemic clamp technique. (2) Acetylcholine (Ach)-dependent vasodilation response and nitric oxide synthase (NOS)-nitric oxide (NO)-cGMP function status were observed in isolated aorta of rats. Results (1) GIR was obviously lower in high fat feed group than that in routine feed group (P
