Lung Cancer Screening with Low-Dose Helical CT in Korea: Experiences at the Samsung Medical Center.
10.3346/jkms.2005.20.3.402
- Author:
Semin CHONG
1
;
Kyung Soo LEE
;
Myung Jin CHUNG
;
Tae Sung KIM
;
Hojoong KIM
;
O Jung KWON
;
Yoon Ho CHOI
;
Chong H RHEE
Author Information
1. Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. kslee@smc.samsung.co.kr
- Publication Type:Original Article ; Comparative Study
- Keywords:
Mass Screening;
Lung Neoplasms;
Tomography, Spiral Computed;
Smoking
- MeSH:
Adenocarcinoma/diagnosis;
Aged;
Aged, 80 and over;
Carcinoma, Non-Small-Cell Lung/diagnosis;
Carcinoma, Squamous Cell/diagnosis;
Comparative Study;
Female;
Humans;
Korea;
Lung Neoplasms/*diagnosis;
Male;
Mass Screening/*methods;
Middle Aged;
Risk Factors;
Tomography, X-Ray Computed/*methods
- From:Journal of Korean Medical Science
2005;20(3):402-408
- CountryRepublic of Korea
- Language:English
-
Abstract:
To determine overall detection rates of lung cancer by low-dose CT (LDCT) screening and to compare histopathologic and imaging differences of detected cancers between high- and low-risk groups, this study included 6,406 asymptomatic Korean adults with >or=45 yr of age who underwent LDCT for lung cancer screening. All were classified into high- (>or=20 pack-year smoking; 3,353) and low-risk (3,053; <20 pack-yr smoking and non-smokers) groups. We compared CT findings of detected cancers and detection rates between high- and low-risk. At initial CT, 35% (2,255 of 6,406) had at least one or more non-calcified nodule. Lung cancer detection rates were 0.36% (23 of 6,406). Twenty-one non-small cell lung cancers appeared as solid (n=14) or ground-glass opacity (GGO) (n=7) nodules. Cancer likelihood was higher in GGO nodules than in solid nodules (p<0.01). Fifteen of 23 cancers occurred in high-risk group and 8 in low-risk group (p=0.215). Therefore, LDCT screening help detect early stage of lung cancer in asymptomatic Korean population with detection rate of 0.36% on a population basis and may be useful for discovering early lung cancer in low-risk group as well as in high-risk group.
