Effect of Movement Restrict on the Expression of 5-HT Receptor Subtypes in Rat Brain
- VernacularTitle:约束应激对大鼠5-HT_(1A)和5-HT_(2A)受体表达的影响
- Author:
Xingqu WU
;
Laiqi YANG
;
Xiaofeng WANG
- Publication Type:Journal Article
- Keywords:
Stress;
Rat;
5-HT receptor;
PCR
- From:Chinese Journal of Clinical Psychology
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the 5-HT mechanism of stress . Methods:The method of polymerase chain reaction (PCR) was used to detect the presence of 5-HT receptor subtypes in the hippocampus,hypothalamic and midbrain of the rat after 30days of movement restrict compared with normal cage control groups (CC) . The specific oligonucleotide primers were synthesized based on the complementary DNA sequence for each of the rat 5-HT 1A and 5-HT 2A receptor subtypes . Results : The expression of 5-HT 1A receptor subtypes in each regions of the rat brain after movement restrict were signifcantly lower than that of the CC groups, and the expression of 5-HT 2A receptor subtype were signifcantly higher( P
