Repair of radius defects using transplanted bone marrow stroma cells: an experimental study
- VernacularTitle:骨髓基质细胞移植治疗骨缺损的实验研究
- Author:
Guiqing WANG
;
Daozhang CAI
- Publication Type:Journal Article
- Keywords:
Bone marrow stroma cells;
Type-Ⅰ Collagen;
Transplantation;
Radius
- From:
Chinese Journal of Trauma
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the treatment effect of transplanted autogenous bone marrow stroma cells (BMS-C) absorbed in the type-Ⅰ collagen matrix in bone repair. Methods Thirty-two adult white New Zealand rabbits were randomly divided into Group Ⅰ and Group Ⅱ. The bone marrow was extracted from tubercle and greater trochanter of femur for culture. Then, the cells were amplified, implanted into type-Ⅰ collagen matrix and further cultured for two weeks. Two weeks later, the cells were implanted into the 1.5 cm radius defect. In the Group Ⅰ, management A (BMS-C+type-Ⅰ collagen) was given to the defect of one radius and management B (control) to the defect of the contralateral radius. In the Group Ⅱ, the defect of one radius was given management A and the defect of the contralateral radius management C (type-Ⅰ collagen).The rabbits were killed 8 and 12 weeks after implantation, the effect of three managements was compared. Results Twelve weeks after implantation, in the management A, all specimens had complete bony union; and in the management B, the specimens were filled with fibrous tissues; in the management C, a little scar formed. Conclusions BMS-C absorbed in the type-Ⅰ collagen can effectively repair bone defect.
