Expression of multidrug resistance-related markers in renal pelvic and ureteral carcinoma
- VernacularTitle:肾盂输尿管癌多药耐药指标的表达意义
- Author:
Yu ZENG
;
Chuize KONG
;
Yuyan ZHU
- Publication Type:Journal Article
- Keywords:
Kidney pelvic;
Ureter;
Carcinoma;
Drug resistance
- From:
Chinese Journal of Urology
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the expression of multidrug resistance-related markers in renal pelvic and ureteral carcinoma. Methods The immunohistochemical expression of P-glycoprotein (P-gp), multidrug resistance-associated protein (MRP), lung-resistance protein (LRP) and glutathione S-transferase Pi (GST-?) were examined in 51 patients with renal pelvic or ureteral carcinoma.The correlation between the expression and some clinicopathological parameters was analyzed. Results The positive expression rate of P-gp、MRP、LRP and GST-? in renal pelvic or ureteral carcinoma was 35.3%(18/51),39.2%(20/51),58.8%(30/51) and 43.1%(22/51) respectively.The rate of P-gp positive staining was increased with the advance of tumor grade (P
