Experimental ultrasonographic study of abdominal aorta in diet-induced hyperhomocysteinemia rabbits
- VernacularTitle:高同型半胱氨酸兔模型腹主动脉超声表现的实验研究
- Author:
Xinghua WANG
;
Fen GAO
;
Jie LI
- Publication Type:Journal Article
- Keywords:
Ultrasonography;
Hyperhomocy steinemia;
Atherosclerosis;
Homocysteine
- From:
Chinese Journal of Ultrasonography
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relation between serum homocysteine(HCY) and the development of atherosclerosis(AS).Methods Diet contained 1% methionine was fed to make models of hyperhomocysteinemia and atherosclerosis in 18 male New Zealand rabbits. Hyperlipemia group was as control group. Ultrasonographic image was performed in 0,4,8 weeks respectively with HP 8500 and recorded the stenosis and plaque of abdominal aorta compared with pathology.Results Stenosis and plaque of abdominal aorta were observed in 4 weeks in high fat diet group. Stenosis and plaque of abdominal aorta were observed in 8 weeks in high methionine diet group.This results were confirmed by pathology anatomy.Satistically,significant correlation was found between AS and hypercholesterolemia or hyperhomocysteinemia respectively.But there was no correlation between hypercholesterolemia and hyperhomocysteinemia. Conclusions Hyperhomocysteinemia is an independent important risk factor of atherosclerosis.
