Development of Korean Standard Brain Templates.
10.3346/jkms.2005.20.3.483
- Author:
Jae Sung LEE
1
;
Dong Soo LEE
;
Jinsu KIM
;
Yu Kyeong KIM
;
Eunjoo KANG
;
Hyejin KANG
;
Keon Wook KANG
;
Jong Min LEE
;
Jae Jin KIM
;
Hae Jeong PARK
;
Jun Soo KWON
;
Sun I KIM
;
Tae Woo YOO
;
Kee Hyun CHANG
;
Myung Chul LEE
Author Information
1. Korean Consortium for Brain Mapping, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea. dsl@plaza.snu.ac.kr
- Publication Type:Original Article ; Comparative Study ; Research Support, Non-U.S. Gov't
- Keywords:
Brain;
Magnetic Resonance Imaging;
Positron-Emission Tomography;
Atlases;
Reference Standards
- MeSH:
Adolescent;
Adult;
Age Factors;
Aged;
Brain/*radiography/*radionuclide imaging;
Comparative Study;
Female;
Fluorodeoxyglucose F18/diagnostic use;
Humans;
Korea;
Magnetic Resonance Imaging/methods;
Male;
Middle Aged;
Positron-Emission Tomography/methods;
Research Support, Non-U.S. Gov't;
Sex Factors
- From:Journal of Korean Medical Science
2005;20(3):483-488
- CountryRepublic of Korea
- Language:English
-
Abstract:
We developed age, gender and ethnic specific brain templates based on MR and Positron-Emission Tomography (PET) images of Korean normal volunteers. Seventy-eight normal right-handed volunteers (M/F=49/29) underwent 3D T1-weighted SPGR MR and F-18-FDG PET scans. For the generation of standard templates, an optimal target brain that has the average global hemispheric shape was selected for each gender. MR images were then spatially normalized by linear transformation to the target brains, and normalization parameters were reapplied to PET images. Subjects were subdivided into 2 groups for each gender: the young/midlife (<55 yr) and the elderly groups. Young and elderly MRI/PET templates were composed by averaging the spatially normalized images. Korean templates showed different shapes and sizes (mean length, width, and height of the brains were 16.5, 14.3 and 12.1 cm for man, and 15.6, 13.5 and 11.4 cm for woman) from the template based on Caucasian (18.3, 14.2, and 13.3 cm). MRI and PET templates developed in this study will provide the framework for more accurate stereotactic standardization and anatomical localization.
