Clinical Significance of Ki-67 Labeling Index in Pituitary Macroadenoma.
10.3346/jkms.2005.20.3.489
- Author:
Kyung Il PAEK
1
;
Seon Hwan KIM
;
Shi Hun SONG
;
Seung Won CHOI
;
Hyeon Song KOH
;
Jin Young YOUM
;
Youn KIM
Author Information
1. Department of Neurosurgery, College of Medicine, Chungnam National University, Daejeon, Korea. neons@cnu.ac.kr
- Publication Type:Original Article ; Comparative Study
- Keywords:
Pituitary Neoplasms;
Ki-67 Antigen;
Recurrence
- MeSH:
Adenoma/metabolism/*pathology/radiography;
Adult;
Aged;
Comparative Study;
Female;
Humans;
Immunohistochemistry;
Ki-67 Antigen/*analysis;
Male;
Middle Aged;
Neoplasm Recurrence, Local;
Pituitary Neoplasms/metabolism/*pathology/radiography
- From:Journal of Korean Medical Science
2005;20(3):489-494
- CountryRepublic of Korea
- Language:English
-
Abstract:
The aim of our study was to investigate the correlation of the proliferative activity of pituitary neoplasms with clinical characteristics and recurrences. Tumor specimens were obtained from 44 consecutive patients with pituitary macroadenomas who underwent surgery between July 1998 and August 2003. Specimens were immediately fixed in 10% buffered formalin and then embedded in paraffin. The Ki-67 antigen was assessed by immumohistochemical analysis using the monoclonal antibody. We investigated the correlation of the Ki-67 labeling index with the following clinical and radiological characteristics: sex, age, presence or absence visual field defect, tumor classification, maximal tumor diameter, Hardy's classification, type of tumor, invasiveness, and recurrence. Our study suggests that the clinical characteristics such as visual field defect and recurrence are correlated with the high Ki-67 labeling index. No statistical differences were observed in the Ki-67 labeling index in relation to the following characteristics: sex, age, tumor classification, maximal tumor diameter, Hardy's classification, type of tumor, and invasiveness into the sphenoid sinus or cavernous sinus.
