Effect of lymphatic reconstruction on pharmacokinetics of FK506 after small bowel transplantation in rats
- VernacularTitle:大鼠小肠移植后淋巴管重建对他克莫司药代动力学的影响
- Author:
Guanglong DONG
;
Xiaoling LIU
;
Weizhong WANG
- Publication Type:Journal Article
- Keywords:
Intestine, small;
Transplantation;
Immunosuppressive agents;
Pharmacokinetics
- From:
Chinese Journal of Organ Transplantation
1996;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of immediately lymphatic reconstruction (LR) after heterotopic small bowel transplantation on pharmacokinetics (absorption and transportation) of FK506. Methods Male Brown-Norway (BN) and Lewis (LEW) rats were divided to two groups. Group A: BN→LEW+LR+FK506 ( n =12); Group B: BN→LEW+FK506 ( n =12). FK506 at a dose of 5?mg/kg per day was taken through stoma. At 1, 4, 7 and 14 postoperative day (POD), venous blood 0.5?ml was obtained on the 1.2 , 2 and 3?h after administration of FK506. Whole blood concentration of FK506 was analyzed by microparticle enzyme immunoassay and a kit of monoclone antibody. Results At the every phase of early period after transplantation (1, 4, 7 POD), the levels of FK506 in plasma were significantly higher in group A than in group B ( P
