Expression of CD_(44)V_5 and nm23-H_1 gene in esophageal cancer
- VernacularTitle:食管癌中CD_(44)V_5和nm23-H_1基因表达及意义
- Author:
Wei KOU
;
Jing WU
;
Xiang YAN
- Publication Type:Journal Article
- Keywords:
esophageal cancer;
CD 44 V 5;
nm23 H 1 gene;
prognosis;
lymph node metastasis
- From:
China Oncology
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To study the expression of CD 44 V 5 and Nm23 H 1 gene products and their significance in esophageal cancer patients.Methods:The expression of CD 44 V 5 and Nm23 H 1 in 85 cases of formalin fixed, paraffin embedded specimens of esophageal cancer were measured by immunohistochemistry S P method. Fifty cases were followed up for 3 years after operation.Results:①The positive expression rate of CD 44 V 5 and Nm23 H 1 was 61.2% 、57 6%, respectively in esophageal cancer.②Overexpression of CD 44 V 5 gene products were closely related with the invasive extent , histopathologic classification , TNM stage ,lymph node metastasis(LNM) and prognosis of Ec( P
