Lipoprotein lipase gene polymorphism in simple obese patients
- VernacularTitle:单纯性肥胖患者脂蛋白脂酶基因多态性
- Author:
Rong LI
;
Qifu LI
;
Lixin GUO
;
Shuping WANG
- Publication Type:Journal Article
- Keywords:
Obesity;
Lipoprotein lipase;
Body fat distribution;
Polymorphism, restriction fragment length
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the impact of lipoprotein lipase (LPL) gene Hind Ⅲ polymorphisms on plasma lipid and body adipose tissue distribution in simple obese patients. Methods The Hind Ⅲ site of LPL gene intron 8 was detennined by PCR-RFLP in 98 simple obese patients and 51 normal controls. Anthropometry and blood lipid levels were also measured. The parameters for regional adipose tissue distribution were measured by computerized tomography (CT). Results In both groups, H + was the major allele. There was no statistically significant difference in frequencies of genotypes or alleles between the two groups. In obese subjects, Hind Ⅲ H + H + genotype was associated with higher level of triglycerides and lower level of high density lipoprotein-cholesterol ( HDL-C) , as compared with the heterozygote (H + H - ) or homozygote ( H - H - ) genotypes (both P
