Inhibitory effect of pioglitazone on TGF-?1 gene expression in renal cortex of diabetic rats
- VernacularTitle:吡格列酮对糖尿病大鼠肾皮质TGF-?_1基因表达的抑制作用
- Author:
Hong LI
;
Fenping ZHENG
;
Yu RUAN
;
Chengjiang LI
- Publication Type:Journal Article
- Keywords:
Diabetic nephropathies;
Pioglitazone;
Rat, Sprague-Dawley;
Transforming growth factor-?;
Cene expression
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic model of SD rats was induced by streptozotocin injected intraperitoneally. Transforming growth factor (TCF)-?1 mRNA level was significantly decreased in renal cortex of diabetic rats by treatment of Pioglitazone. The result suggests that the protection of Pioglitazone against diabetic nephropathy seems to be related to the decrease of TGF-?1 gene expression in renal cortex.
