11? Hydroxysterold dehydrogenases and type 2diabetes mellitus
- VernacularTitle:11?-羟类固醇脱氢酶与2型糖尿病
- Author:
Na CHEN
;
Bing YAO
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,non-insulin-dependent;
11?-Hydroxysteroid dehydrogenases INsulin resistance Obesity
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
11? Hydroxysterold dehydrogenases (11?-HSDs )catalyse the interconversion of active glucocorticoids(cortisol,corticosterone )and their inert 11?-keto derivatives(cortisone,11-dehydrocorticosterone)They play an important role in regulating the local glucocorticoids activities.Glucoeorticoids can induce insulin resistance.The alteration of 11?-HSD activities in tissues such as liver ,adipose tissue, is closely relevant to some common disorders,including obesity and type 2diabetes mellitus.
