A preliminary study on the efficacy and mechanism of Chinese traditional medicine Zeguilongshuang capsule for the treatment of benign prostatic hyperplasia
- VernacularTitle:泽桂癃爽胶囊治疗良性前列腺增生疗效和作用机理的初步研究
- Author:
Kai ZHANG
;
Xinyu YANG
;
Jun ZHANG
- Publication Type:Journal Article
- Keywords:
Prostatic hyperplasia;
Benign;
Chinese traditional medicine
- From:
Chinese Journal of Urology
2001;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To conduct a preliminary study on the efficacy and mechanism of Chinese traditional medicine Zeguilongshuang capsule for benign prostatic hyperplasia (BPH). Methods 20 patients with BPH were randomized into treatment group and control group (10 patients in each group).The medical history,International Prostate Symptom Score (IPSS),digital rectal examination,ultrasonography and uroflowmetry were done at the baseline.Patients in the treatment group used two Zeguilongshuang capsules three times per day for one month with repeated IPSS and above-mentioned examinations. They underwent prostatectomy on the next day when the treatment was completed.Patients in the control group received prostatectomy directly. After the pathological diagnosis of BPH was made,the expression of basic fibroblast growth factor (bFGF),platelet-derived growth factor (PDGF) and androgen receptor (AR) in the BPH tissue were assessed by immunohistochemistry. Results Patients in the treatment group reported improvement of low urinary tract symptoms, the mean IPSS decreased by 11.2%,the mean volume of the prostate reduced by 16.7%,and the mean maximum flow rate increased by 35.6%.Compared with the control group,the expression of bFGF in BPH tissue was down regulated ( P
