Prostate specific membrane antigen expression of prostatic adenocarcinoma and the relationship between PSMA expression and histologic grade
- VernacularTitle:前列腺特异性膜抗原表达的临床意义
- Author:
Hao ZENG
;
Hong LI
;
Xiuhui ZHANG
- Publication Type:Journal Article
- Keywords:
Prostatic neoplasms;
Carcinoma;
Prostate specific membrane antigen
- From:
Chinese Journal of Urology
2001;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between PSMA expression and histologic grading of prostatic carcinoma. Methods Different prostatic tissues and non-prostatic tumors (PCa 70,prostate intraepithelial tumor 21,BPH 20,nonprostatic malignancies 30) were analysed for the expression of PSMA by using PSMA mono-clonal antibody and ABC immunohistochemical staining. Results All prostatic tissues but 2 cases of prostatic carcinoma and 4 cases of benign prostate hyperplasia were stained positively,while all of the non-prostatic tumors were stained negatively.There was a negative correlation between PSMA expression and histologic grading of prostatic adenocarcinoma. Conclusions PSMA was prostatic organic specific and could be a prognostic marker of prostate adenocarcinoma.
