Study of toxic effect of degradable polymers on peripheral nerve
- VernacularTitle:可降解材料对外周神经的毒性作用研究
- Author:
Qingtang ZHU
;
Jiakai ZHU
;
Gang CHENG
- Publication Type:Journal Article
- Keywords:
Biomaterials;
Biocompatibility;
Peripheral nerves;
Tissue engineering;
Chitosan
- From:
Chinese Journal of Microsurgery
2000;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective Investigate the toxicity of polylactic acid,polyglacolic acid and chitosan on peripheral nerves,so as to detect the polymers with good biocompatibility to fabricate the scaffold of tissue engineered nerve Method Fifteen Sprague Dawley rats were divided into 3 groups randomly;polylactic acid,polyglacolic acid and chitosan were implanted into the sciatic nerves respectively.7 weeks later,the nerves with polymers were harvested and inspected by macroscopy and light microscope. Results There was mild hypertrophy of fibrous connective tissue within the nerves in each group.However,the nerve fibers were intact The polymers were surrounded by a pseudocapsule,and lymphocytes and macrophages infiltrated.The pseudocapsule coating chitosan was the thickest. Conclusion polylactic acid, polyglacolic acid and chitosan have no toxic effect on peripheral nerves.
