Study of CD4~+CD25~+ regulatory T cells in NIK mutated mice
- VernacularTitle:NF-?B诱导激酶基因突变对CD4~+CD25~+调节性T细胞产生的影响
- Author:
Shijie SUN
;
Dan LIU
;
Chunlei YU
- Publication Type:Journal Article
- Keywords:
NF-?B inducing kinase(NIK);
aly mice;
CD4+CD25+ T cell;
Autoimune diseases
- From:
Chinese Journal of Immunology
1985;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the relationship betwen the mechanism of autoimmune disease and CD4+CD25+ T cell population in NIK mutated mice-aly mice.Methods:NIK mutated mice-aly/aly mice were used as model,aly/+mice as NIK normal control;cell populations were determined by FACS and the thymus structure were analyzed by immunohistochemistry.Results:The CD4+CD25+CD8- population were remarkably decreased in aly mice;and the UEA-1 positive cells were absent in aly mice.Conclusion:The autoimmune disease in aly mice might be the result of deceased the CD4+CD25+ population;the UEA-1 positive cells might play an important role in the development of CD4+CD25+ population. [
