The expansion and differentiation effects of Staurosporine on CMK cell
- VernacularTitle:Staurosporine对CMK细胞增殖和分化的影响
- Author:
Meirong ZHAO
;
Yiduo XU
- Publication Type:Journal Article
- Keywords:
Staurosporine(ST);
CMK cell;
Expansion and differentiation
- From:
Chinese Journal of Immunology
1985;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine the expansion and differentiation effect of Staurosporine on human megalaryoblastic cell line(CMK).Methods:With MTT and colony assaies.Results:Staurosporine could densitily inhibited the expansion of CMK cell,IC 50 was 50 nmol/L,Staurosporine could inhibite CMK cell at G 1 phase,then decreased the cells of S and G 2M phases,ST in 80 nmol/L improve the expression of CD41 antigen in CMK cell,induce its differentiation.Conclusion:ST as a new kind of anti-tumor facor has different mechanism with other anti-tumor drugs. [
