The Toxic Effect of 2-Methyl-4-chlorophenoxyacetic Acid in Male Mice
- VernacularTitle:除草剂2-甲-4氯苯氧乙酸对雄性小鼠的毒作用
- Author:
Shuhua ZHAO
;
Jingshun LI
;
Lan BAI
- Publication Type:Journal Article
- Keywords:
Pesticides;
Toxicity;
Endocrine;
Male mice
- From:
Journal of Environment and Health
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the toxic effects of2-methyl-4-chlorophenoxyacetic acid(MCPA)in male mice.Meth-ods The Kunming male mice were divided into4groups,10male mice per group.The control group were purfused into stom-ach by distilled water,the other three groups were perfused into stomach by20,100and200mg /kg MCPA,once a day,6times per week,continuously for17days.The body weight ,T 4 ,TSH,cholesterol,the ratio of spleen and testis to body weight and the specific activity of LDH,SDH in the testis were analyzed.Results The body weight of mice in MCPA-exposure groups in-creased more slowly than that in the control group.The contents of TSH in serum and ratio of spleen to body weight in200mg/kg group were significantly lower than those in control group.The contents of cholesterol in serum increased with the increases of MCPA-exposure doses.The contents of T 4 in serum were significantly higher in20mg /kg group and lower in200mg /kg group compared with that in control group.The ratio of the testis to body weight reduced with increase of the MCPA-exposure doses,and the specific activity of LDH in the testis of MCPA-exposure groups increased significantly,but the specific activity of SDH in the testis of MCPA-exposure groups revealed no significant variations compared with that of control group.Conclusion MC-PA inhibited the growth of male mice,resulted in endocrine disorder,the atrophy of spleen,and presented the toxicity of repro-ductive system.
