Influence of dopamine on renal immunocompetence in brain death rats
- VernacularTitle:多巴胺预处理对脑死亡大鼠肾免疫原性的影响
- Author:
Fang LIU
- Publication Type:Journal Article
- Keywords:
Dopamine;
Brain death;
Immunocompetence;
Rats;
Kidney
- From:
Chinese Journal of Organ Transplantation
1996;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of dopamine pretreatment on the renal immunocompetence in a rat brain death animal model.Methods Dopamine (2, 6, 10 and 14??g?kg -1 ?ml -1 ) was continuously infused intravenously in a rat brain death animal model. 6 h later, the kidney was removed for immunohistochemical assay. Results Dopamine pretreatment could inhibit the infiltration of renal monocytes, and the expression of MHC II and P selektin in a dose dependent manner.Conclusion Dopamine pretreatment could obviously reduce the renal immunocompetence in a rat brain death model.
