Helicobacter pylori-related Peptic Ulcer Disease.
- Author:
Seung In SEO
1
;
Hak Yang KIM
Author Information
1. Division of Gastroenterology, Department of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea. bacter@hallym.or.kr
- Publication Type:Review
- Keywords:
Helicobacter pylori peptic ulcer;
Epidemiology;
Treatment
- MeSH:
Amoxicillin;
Anti-Inflammatory Agents, Non-Steroidal;
Aspirin;
Clarithromycin;
Drug Resistance, Microbial;
Epidemiology;
Helicobacter pylori;
Helicobacter*;
Hemorrhage;
Humans;
Incidence;
Korea;
Peptic Ulcer*;
Prevalence;
Proton Pumps;
Recurrence;
Ulcer
- From:Korean Journal of Medicine
2014;86(6):655-663
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Although the worldwide prevalence of Helicobacter pylori (H. pylori) infection has decreased, peptic ulcer disease (PUD) remains prevalent due to increased usage of non-steroidal anti-inflammatory drugs (NSAIDs), such as aspirin. In recent years, the prevalence of H. pylori infection in PUD cases and the distribution of PUD have changed in Korea. The incidence of idiopathic H. pylori-negative ulcers has increased, and research is needed to determine the cause of these idiopathic ulcers. The eradication of H. pylori infection decreases PUD recurrence, and plays a crucial role in the treatment of PUD. The H. pylori test-and-treat strategy is beneficial for patients starting NSAIDs and long-term aspirin users with a history of bleeding ulcers. Although the H. pylori eradication rate is declining steadily due to antibiotic resistance, especially to clarithromycin, current guidelines still recommend standard triple therapy, including a proton pump inhibitor, amoxicillin, and clarithromycin, as a first-line therapy. Recently, various treatment regimens, including sequential or concomitant therapies, have been developed in an attempt to overcome the low eradication rate observed with standard triple therapy. The aim of this article is to review recent trends in H. pylori-related PUD, focusing on epidemiology and treatment strategies.
