Expressions of Fas,FasL,Bcl-2 and Bax proteins in thyroid tissue from patients with Graves′ disease
- VernacularTitle:Graves病患者甲状腺组织中凋亡蛋白Fas、FasL、Bcl-2和Bax的表达
- Author:
Jialing WANG
;
Yaping ZHAO
;
Zhiyong FAN
;
Hejun WU
;
Wei ZHOU
;
Zehong LIU
- Publication Type:Journal Article
- Keywords:
Graves′ disease;
Apoptosis;
Antigens, CD95;
Bcl-2;
Bax;
Immunohistochemistry
- From:
Chinese Journal of Endocrinology and Metabolism
1985;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of the expressions of Fas, FasL, Bcl-2 and Bax in thyroid tissue with the pathogenesis in Graves′ disease (GD). Methods Thyroid tissues from 54 patients with GD and 10 patients with thyroid adenoma (paraadenoma tissue as normal controls) were studied for Fas, FasL, Bcl-2 and Bax expressions in the thyrocytes and lymphocytes by immunohistochemical method. Quantitative analysis was performed by Mias 99 pathological image system. Results (1) The positive granule area, average light density and integrated light density of Fas, FasL, Bcl-2 and Bax in the thyroid tissue from patients with GD were higher than those from normal controls (P
