Effect of methimazole and methotrexate on immune function in Graves' disease
- VernacularTitle:甲巯咪唑与甲氨蝶呤对Graves病免疫功能的影响
- Author:
Chu ZHANG
;
Jiatao LOU
;
Yin WU
;
Lizhen MA
;
Fengying PENG
- Publication Type:Journal Article
- Keywords:
Graves′ disease;
Methimazole;
Methotrexate;
Immune system
- From:
Chinese Journal of Endocrinology and Metabolism
1985;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Observation revealed the abnormalities (increased CD 4 and Th, decreased Tc) in patients of Graves′ disease, and these abnormalities were not significantly adjusted after 6 weeks of treatment with methimazole (MMI), or with MMI and methotrexate (MTX), though the soluble interleukin-2 receptor and thyroid autoantibodies slightly decreased in both groups. However, the addition of MTX did not show any better effects than MMI alone in the treatment.
