Relationship between thyrotropin receptor gene mutation and toxic multinodular goiter
- VernacularTitle:TSH受体基因突变与毒性多结节性甲状腺肿的相关性
- Author:
Fengjun WANG
;
Baodong GAI
;
Zhongtian JIN
;
Deheng ZHANG
- Publication Type:Journal Article
- Keywords:
Receptors, thyrotropin;
Mutation;
Toxic multinodular goiter
- From:
Chinese Journal of Endocrinology and Metabolism
1985;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
DNA was extracted from thyroid nodular tissue in 16 patients with toxic multinodular goitor (TMG). After PCR, the product of PCR was sequenced, and 3 cases with point mutation (A1964T) and 2 cases with insertion mutation (a G was inserted after nucleotide 1928) in TSH receptor gene were found. It is postulated that these mutations may play an important role in the pathogenesis of TMG.
