The expression of protein kinase C subforms in renal cell carcinoma and its clinical significance
- VernacularTitle:肾癌组织蛋白激酶C亚型的表达及意义
- Author:
Zeliang LI
;
We LIANG
;
Chuize KONG
- Publication Type:Journal Article
- Keywords:
Kidney neoplasms;
Carcinoma;
Protein kinases
- From:
Chinese Journal of Urology
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the expression of three protein kinase C subforms in renal cell carcinoma.MethodsThe expression of cPKC?,cPKC? Ⅱ and aPKC? in renal cell carcinoma were detected by immunohistochemical method(S-P method) and by in situ hybridization.ResultsPositive rate of cPKC? ?cPKC? Ⅱ and aPKC? was 68.4%,34.2% and 44.7% respectively in renal cell carcinoma.Positive rate of cPKC? in stage T 2～T 4 tumors was 80.9%(17/21) and 52.9%(9/17) in T 1(P 0.05).The positive expression of cPKC? in deadly cases was significantly higher than in survivers (P
