Concomitant chemoradiotherapy for prevention of recurrence and metastasis in the surgical treatment of salivary adenoid cystic carcinoma
- VernacularTitle:同期放化疗预防涎腺腺样囊性癌术后的复发和转移
- Author:
Moyi SUN
;
Xiaoguang HU
;
Xiaobing CHENG
- Publication Type:Journal Article
- Keywords:
Radiotherapy;
Drug therapy;
Salivary gland neoplasmes;
Adenoid cystic carcinoma;
Recurrence;
metastasis;
Hydroxycamptothecin
- From:
Journal of Practical Stomatology
1996;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To evaluate the effect of concomitant chemoradiotherapy for the prevention of recurrence and metastasis of postoperative salivary adenoid cystic carcinoma(SACC).Methods: 14 cases of salivary adenoid cystic carcinoma after operation were treated with concomitant chemoradiotherapy. Regular radiotherapy of 60 Gy and chemotherapy with hydroxycamptothecin (HCPT) at 10 mg/m 2 , 3 times a week, were administered. HCPT was given in 1st, 2nd, 4th and 5th week. Recurrence and metastasis of SACC after operation were observed using CT, MRI, ultrasonography and X ray. Results: After 3～17 months' follow up, relapse free survival was 100%. No recurrence and metastasis of SACC after operation were found. Adverse reactions of the chemotherapy were nausea, vomiting and leukopenia. After suspended in a short time and using ondansetron and /or G CSF the chemotherapy of HCPT was continued and completed. Conclusion: concomitant chemoradiotherapy of HCPT and radiotherapy can prevent recurrence and metastasis of SACC after operation. The efficacy of long term needs further observation.
