TIL phenotype alteration in oral cancer tissue follwing induction chemotherapy via subcutaneous implantable drug pump
- VernacularTitle:经皮下埋植泵诱导化疗治疗口腔癌TIL表型研究
- Author:
Wei TANG
;
Weidong TIAN
;
Shengwei LI
- Publication Type:Journal Article
- Keywords:
Mouth neoplasms;
Induction chemotherapy;
Tumor infiltrating lyphocytes
- From:
Journal of Practical Stomatology
1996;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
objective: To study the effects of induction chemotherapy via subcutaneous implantable drug pump on local immune status. Methods: 47 cases with node negative oral cancer were treated with MTX, CDDP, PYM via subcutaneous implantable drug pump(in 27 cases), or via vein for case control trial(in 20 cases). Local immune status of tumor tissue was detected by immunohistochemical technique before and after treatment. Results: The effectiveness of treatment with the drugs via subcutaneous implantable drug pump (DSIP) was observed in 21 out of 27 cases (77.8%) and that with the drugs via vein(DV) was in 13 out of 20(65.0%) respectively( P 0.05), while the number of positive cells of CD 4 and CD 4/CD 8 in the cases treated with DV was decreased( P
