Methodological Experimental Study on Percutaneous Regional IsolatedHepatic Perfusion Combined with Charcoal Hemoperfusion
- VernacularTitle:经皮局部隔离肝脏灌注化疗合并血液灌流方法学实验研究
- Author:
Shichen LIU
;
Renjie YANG
;
Hongzhi ZHANG
;
Linzhong ZHU
- Publication Type:Journal Article
- Keywords:
animals ,laboratory;
isolated liver;
perfusion therapy;
interventional radiology
- From:
Journal of Practical Radiology
1991;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate methods and feasibility of percutaneous regional isolated hepatic perfusion combined with charcoal hemoperfusion(PRIHP-CHP).Methods Four out of 12 dogs underwent the procedure of routine transhepatic arterial infusion(TAI) as control group, 8 underwent PRIHP-CHP as experimental group. Adriamycin was used in our study, the concentration of plasma in hepatic vein and systemic vein was detected in both groups. Results All the procedures were successful in the PRIHP-CHP group eight, but 1 dog died because of air embolization. The average procedure duration for each was (132.3?15.3) minutes. The peak level of adriamycin concentration in hepatic vein and systemic in TAI were (3709.676?385.723) ng/ml and (1576.140?226.933) ng/ml respectively. In PRIHP-CHP, the peak level were (4653.420?430.204) ng/ml and (433.612?40.501) ng/ml. There were statistically significant differences between TAI and PRIHP-CHP (?
