Nuclear Factor-?B and Colon Cancer
- VernacularTitle:细胞核因子-?B与大肠癌
- Author:
Bin WU
;
De SHI
- Publication Type:Journal Article
- Keywords:
Nuclear factor kappa gene binding Apopotosis Malignant tumor Colon cancer
- From:
Chinese Journal of Bases and Clinics in General Surgery
2003;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between nuclear factor ?B (NF ?B) and the occurrence, metastasis, and treatment of colon cancer. Methods The literature on the structure and the property of molecular biology of NF ?B, the relationship between NF ?B and apopotosis, malignant tumor and colon cancer were reviewed.Results NF ?B had action of antiapopotosis. The occurrence of malignant tumor had close relation with the oncogene by NF ?B, the metastasis of malignant tumor was that cell of cancer escaped the killing and supervising of immunity by NF ?B. NF ?B affected the occurrence and metastasis of colon cancer by regulating c myc, Cox2, ICAM 1.Conclusion NF ?B has important action in the occurrence and metastasis of colon cancer. It will become a new target of treatment.
