Toxicity of Formaldehyde on Germ Cells of Male Mice
- VernacularTitle:甲醛对雄性小鼠生殖细胞的毒性
- Author:
Ying XIE
;
Yizhen YI
;
Mingde TANG
- Publication Type:Journal Article
- Keywords:
Formaldehyde;
Sperm;
Abnormalities;
Sperm count
- From:
Journal of Environment and Health
1992;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the general toxicity of formaldehyde on germ cells and its effects on the SDH activity in testicle tissue of mice. Methods The 30 male Kunming mice were divided into 5 groups. 3 groups as exposure groups were in-traperitoneally injected with formaldehyde at doses of 0.20, 2.00 and 20.00 mg/kg respectively and continuously for 5 days. The other 2 groups were considered as controls positive and negative group. The pathological changes of testicle tissue of mice were observed by microscopy and the activity of SDH in testicle tissue was determined. The sperm count and the abnormal sperm's heads were observed by microscopy. Results Formaldehyde could induce the degeneration and necrosis in germ cells of mice. With the increases of the exposure doses of formaldehyde, the sperm count and the activity of SDH in testicle tissue of mice decreased (P
