Ralationship between hepatocellular apoptosis and glycogen contents during cold preservation-reperfusion of liver and its mechanism
- VernacularTitle:肝脏低温保存-再灌注后的变化及机制
- Author:
Lijun TANG
;
Fuzhou TIAN
;
Yu WANG
- Publication Type:Journal Article
- Keywords:
Liver;
Organ preservation;
Reperfusion injury;
Liver glycogen
- From:
Chinese Journal of Organ Transplantation
1996;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study relationship between hepatocellular apoptosis and glycogen contents during cold preservation-reperfusion of liver and its mechanism. Methods Rat liver models with different contents of glycogen were established and the rats were divided into 4 groups (A, B, C and D). During cold reservation-reperfusion of liver, the changes in hepatocellular apoptosis and tissue SOD, GSH and MDA were observed in the groups. Results After cold preservation for 9 h in each group, 60?min reperfusion could result in obvious apoptosis in livers. There was difference in the numbers of apoptotic hepatocytes among all the groups. At the same time, there also were significant difference in the levels of SOD, GSH and MDA in liver tissue among the four groups.Conclusion Intracellular abundant glycogen may significantly depress hepatocellular apoptosis during hepatic cold preservation-reperfusion by decressing oxygen free radicals.
