Inhibitory effect of L-arginine on cardiac allograft vasculopathy in a rat cardiac allograft model
- VernacularTitle:左旋精氨酸对大鼠心脏移植物血管病变的抑制作用
- Author:
Qinghua ZHANG
;
Zhifa YAO
;
Wangfu ZANG
- Publication Type:Journal Article
- Keywords:
Arginine;
Heart transplantation;
Endothelium, vascular;
Nitric oxide
- From:
Chinese Journal of Organ Transplantation
1996;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the inhibitory effect of L-arginine on cardiac allograft vasculopathy (CAV) and its possible mechanisms.Methods The rat cardiac allograft model was used. In the control group (n=26), L-arginine was not administered after heterotopic cardiac transplantation, and the other 21 rats (experimental group) received administration of L-arginine ( 800?mg/kg every day, in drinking water) after heart transplantation. CAV score was evaluated and plasma nitric oxide (NO) was measured at 2 and 3 months after transplantation. Results Graft survival rate 2 months after transplantation was significantly (P
