The association of ND-1 gene point mutations of mit ochondrial DNA with type 2 diabetes mellitus
- VernacularTitle:线粒体DNA ND-1基因点突变与2型糖尿病的关系
- Author:
Jie QIAN
;
Lirong ZHANG
- Publication Type:Journal Article
- Keywords:
DNA, mitochondrial;
Point mutation;
Dia betes mellitus, non-insulin-dependent (Chin J Endocrinol Metab, 2003,19:46-47)
- From:
Chinese Journal of Endocrinology and Metabolism
1985;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
In type 2 diabetic patients the f re quencies of point mutations 3316G→A and 3394T→C in mitochondrial DNA (mt DNA) were 3.9% (6/152) and 5.3% (8/152) respectively, which were significantly higher than those in normal controls and patients with coronary heart disease. This fi nding suggests that mtDNA 3316G→A and 3394T→G mutations are related to type 2 diabetes.
