Clinical significance of serum metalloproteinase mat rix-9 and its tissue inhibitor-1 in type 2 diabetic patients with nephropathy
- VernacularTitle:2型糖尿病肾病患者血清金属蛋白酶9及其组织抑制因子1水平变化的临床意义
- Author:
Xiaoling LI
;
Xiulan GE
;
Shengou SU
- Publication Type:Journal Article
- Keywords:
Matrix metalloproteinases;
Tissue inhib itor of metalloproteinase-1;
Diabetic nephropathies (Chin J Endocrinol Metab, 2003,19:52-53)
- From:
Chinese Journal of Endocrinology and Metabolism
1985;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Serum metalloproteinase matrix (M MP )-9, tissue inhibitor of metalloproteinase (TIMP)-1 and type Ⅳ collagen level s were measured in patients with diabetic nephropathy (DN). The severity of DN w as determined by urinary albumin excretion rate. The results show that signific ant increases of serum TIMP-1 and type Ⅳ collagen depend on severity of DN, wh ile MMP-9 tends to decline. TIMP-1 and MMP-9 seem to participate in the patha genesis of DN.
