Changes of IL-1, TL-6, TGF-p and FasL expressed by Sertoli cell in testis infection
- VernacularTitle:睾丸局部感染时Sertoli细胞IL-1、IL-6、TGF-?和FasL的变化
- Author:
Guangjie CHEN
;
Weiyi LI
;
Yebin XI
- Publication Type:Journal Article
- Keywords:
Sertoli cell;
Immune regulation;
TGF-3;
FasL
- From:
Chinese Journal of Immunology
1985;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the effect of immune regulation of the rat Sertoli cells in testis infection. Methods: UU and Escherichia coh'(E coli) were injected into the bladders of rats, which mimics the ascending infection pathway, while using culture medium injection as control. After 1 week, 2 weeks, 3 weeks respectively, the rats were sacrificed to observe the pathological changes in testis section. Sertoli cells were separated and obtained from rat testis, then experiments were designed to use the immunohistochemical staining to examine the different level of IL-1, IL-6, TGF-P and FasL among control ,UU and E coli infected groups.Results:Compared with control, in UU and E.coli infected group, the level of IL-1 increased ,the level of IL-6 decreased, the levels of TGF-P and FasL increased. Conclusion: Sertoli cell can play the role of immune regulation, with the expressing changes of IL-1, IL-6, TGF-P and FasL in the infection of testis in rat.
