The effect of Glycyrrhizinatis on serum IgE level of asthmatic rat model and pa- tients with asthma
- VernacularTitle:甘利欣对大鼠哮喘模型及哮喘患者血清IgE水平的影响
- Author:
Zhaoxia WANG
;
Guizhen YANG
;
Lijun SONG
- Publication Type:Journal Article
- Keywords:
Glycyrririzinatis;
Asthma;
Rat;
SenunlgE
- From:
Chinese Journal of Immunology
1985;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effect of glycynhizinatis on serum IgE level of rat model and patients with asthma.Methods:Trie rats were divided into four groups randomly: normal control, asthmatic model, model treated with GL, model treated with DS. The rats were sensitized and challenged with ovalbumin to establish an asthmatic model. The established models were measured by breathing curves, pathological changes in pulmonary tissue slices and the level of serum IgE. Furthermore, serum IgE level of patients with asthma was also detected. Results: High amplitude of breathing curve and fast rhythm were showed in group of asthmatic model, there were more inflammatary cells infiltration in the tiny bronchial wall, hyperplasia of cup-shaped cells and thicker smooth muscle in the pulmonary tissue slices. Compared with normal control, the level of serum IgE in model group increased obviously. The rats treated with glycyrrhizinatis showed low amplitude of breathing curve, decreasing inflammatary cells infiltration in pulmonary tissue slices of tiny bronchial wall, no hyperplasia of cup-shaped cells, and decreased serum IgE level. There were no significant difference between the groups of GL and DS. At the same time, the serum IgE level in patients with asthma was observed. The results showed that the level of serum IgE was higher in patients with asthma than that in normal control (P
