Changes and its clinical significance of natural kill cell and T lymphocyte subsets in parkinson disease patients
- VernacularTitle:帕金森病患者NK细胞亚群及T淋巴细胞亚群变化的临床意义
- Author:
Feng TAN
;
Wei GU
;
Too HUANG
- Publication Type:Journal Article
- Keywords:
Parkinson disease;
Subsets of natural kill cell;
T lymphocyte subsets;
FCM
- From:
Chinese Journal of Immunology
1985;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
CD4+ ..CDS+ -.CD4+ /CDS+ was decreased more significantly in those patients who were older, severe, demential and depressive. Conclusion:Severe natural kill cell and T lymphocyte immune functional decline and disbalance were observed in PD patients. The significant decline of the levels of CD3+ ,CD4+ .CD8+ ,CD4+ /CD8+ in PD patients might be closely related to it's pathogenesis. The levels of CD3+ ,CD4+ ,CD8+ CD4+/CD8+ was even significantly lower in older, severe,dementia and depressive patients, so the levels of natural kill cell and T lymphocyte subsets can provide basis for evaluating severity .progression and prognosis of disease in PD. It was a new connotation for the study of PD on prevention and therapy in the future.
