Distribution of pegylated liposmal doxorubicin in animal model of tongue cancer
- VernacularTitle:舌癌周注射脂质体—阿霉素系统的药物分布规律的实验研究
- Author:
Shaowei CHEN
;
Jian PAN
;
Lin ZHOU
- Publication Type:Journal Article
- Keywords:
Tongue cancer;
Drug therapy;
Liposomes;
Doxorubicin
- From:
Journal of Practical Stomatology
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
objective: To observe the distribution of pegylated liposmal doxorubicin(PLD) in animal model of tongue cancer. Methods: Tongue cancer model was established in 40 golden hamster, PLD or free doxorubicin at the dose of 9 mg/kg was injected perifocally into each of 20 mice, the concentration of the drugs in lypmph node and blood was measured with HPLC. Results: After injection of free ADM peak concerntration in blood was acheived in 3 h and in lymph nodes in 1 h, while after injection of PLD, that was in 16 and 6 h respectively. The concertration of PLD was heigher than that of ADM in both blood and lymph node from 16 or 6 h till 216 h after injetion.Conclusion: PLD can be regarded as valuable drug delivery system in the treatment of oral cancer.
