Embolization effect of 5-Fu gelatin microsphere(FGM) in external carotid artery branches in dogs
- VernacularTitle:5-氟尿嘧啶明胶微球栓塞犬颈外动脉分支的实验研究
- Author:
Qinqin MA
;
Xinghua FENG
;
Qingjiang MENG
- Publication Type:Journal Article
- Keywords:
Fluorouracil;
Gelatin;
Microsphere;
Embolization;
Digital subtraction angiography
- From:
Journal of Practical Stomatology
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
objective: To evaluate the embolization effect of 5 Fu gelatin microsphere(FGM) in oral and maxillofacial region.Methods: FGM was prepared with drug load of 12% and encapsulation of 85%. After irridiated with 60 Co, FGM was suspended into 76% of meglumine diatrizoate, and then perfused into external maxillary artery and lingual artery in 8 dogs under X ray observation. 4 dogs were used in each artery embolization. Blood flow velocity and volume in the arteries were tested at different time after embolization; all the data were analyzed statistically. The sections of embolized tissue at different time were examined microscopically. Results: Before and 1 h, 48 h and l month after ombolization the blood flow volume(ml/min) in external caroted artery was 43?5.0, 31.0?4.5, 26.5?4.0 and 35.0?30; that in external maxillary artery 5.0?1.5, 0.5?1.0, 2.5?1.0 and 3.0?1.5; in ligual artery 3.5?1.0, 0.5?0.5, 0 and 0; in internal maxillary artery 17.0?4.0, 19.5?4.0, 19.0?4.5 and 21.0?3.5, respectively. Stuff of the cavity of the corresponding arteries by FGM were found with histological examination. Conclusion: FGM can embolize artery completely.
