Air Pollutant PM2.5Monitoring and Study on Its Genotoxicity
- VernacularTitle:大气细颗粒物污染监测及其遗传毒性研究
- Author:
Wenli ZHANG
;
Dongqun XU
;
Jiusi CUI
- Publication Type:Journal Article
- Keywords:
Air pollution;
Fine particles;
DNA damage
- From:
Journal of Environment and Health
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate and compare PM2.5pollution levels in Taiyuan and Beijing and to study the DNA damage induced by PM2.5.Methods PM2.5pollution levels in Taiyuan with coal smoke pollution and in Beijing with mixing air pollution typed by coal smoke and automobil exhaust were monitored,and the DNA damage induced by PM2.5was detected by single cell gel-electrophoresis(SCGE)(Comet assay)using human alveolar epithelial cell line A549(A549cells).Results The PM2.5pollution levels in Taiyuan and Beijing during winter were0.132-0.681mg /m 3 and0.028-0.436mg /m 3 respective-ly.PM2.5could induce DNA damage in A549cells after exposure to doses of5,50and200?g /ml for12h and24h-incuba-tion.Compared with the negative control group,there were significant differences(P
