Aging attenuates the neuroprotective effect by preconditioning with 3-nitropropionic acid
- VernacularTitle:年龄因素对3-硝基丙酸预处理对神经保护作用的实验研究
- Author:
Hongge LI
;
Shenggang SUN
;
Etang TONG
- Publication Type:Journal Article
- Keywords:
Succinate dehydrogenase;
Adenosine;
Hypoxia, bain
- From:
Chinese Journal of Geriatrics
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of aging on neuroprotection by preconditioning with 3-nitropropionic acid (3-NPA) and the relationship between aging and adenosine receptor. Methods Population spike amplitude (PSA) in region CA 1 in hippocampal slices was measured during 15 min hypoxia and 45 min posthypoxic recovery from adult and aged mice, which were pretreated in vivo with a single intraperitoneal injection of 3-NPA (20 mg/kg). Posthypoxic PSA recovery was also observed after perfusion with selective agonist or antagonist of adenosine A 1 and A2a receptors. Results Posthypoxic recovery of PSA increased from 26.1?12.2% in control slices to 92.9?15.3% in pretreated slices from adult (P
